Methods of treating solid tumors with CCR2 antagonists

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United States of America Patent

PATENT NO 11154556
APP PUB NO 20190209573A1
SERIAL NO

16241391

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Abstract

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The present disclosure provides, inter alia, methods of treating a solid-tumor by administering an effective amount of a Chemokine Receptor 2 (CCR2) antagonist. Also provided herein are methods of reducing the number of macrophages in a solid tumor microenvironment, said method comprising administering effective amount of a Chemokine Receptor 2 (CCR2) antagonist. In an additional aspect, the current disclosure further provides methods of increasing the number CD8+ T cells in a solid tumor microenvironment, said method comprising administering effective amount of a Chemokine Receptor 2 (CCR2) antagonist. In some embodiments, the CCR2 antagonist has the formula I:

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Patent OwnerAddress
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA1111 FRANKLIN STREET 12TH FLOOR OAKLAND CA 94607-5200

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Campbell, James J San Jose, US 21 76
Hwang, Samuel Oakland, US 5 6
Singh, Rajinder Belmont, US 471 10698
Wu, Xuesong Oakland, US 10 8

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