Biodegradable lipids for the delivery of active agents

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United States of America Patent

PATENT NO 11590229
SERIAL NO

17651029

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Abstract

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The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

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Patent Owner(s)

Patent OwnerAddress
ALNYLAM PHARMACEUTICALS INC300 THIRD STREET 3RD FLOOR CAMBRIDGE MA 02142-1110

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Akinc, Akin Cambridge, US 106 3013
Jayaraman, Muthusamy Cambridge, US 93 3378
Kandasamy, Pachamuthu Cambridge, US 37 86
Maier, Martin Cambridge, US 248 3850
Manoharan, Muthiah Cambridge, US 474 16991
Matsuda, Shigeo Cambridge, US 37 444
Rajeev, Kallanthottathil G Cambridge, US 241 7535

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