Analogs of thalidomide as potential angiogenesis inhibitors
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United States of America Patent
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Jan 22, 2008
Grant Date -
Apr 22, 2004
app pub date -
Feb 26, 2002
filing date -
Feb 27, 2001
priority date (Note) -
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Abstract
A number of thalidomide metabolites having superior anti-angiogenic properties have now been isolated and identified. In addition, thalidomide analogs that mimic the effects of the isolated and identified active thalidomide metabolites, and variations of such thalidomide analogs, have been developed. Such thalidomide analog compounds show enhanced potency in the inhibition of undesirable angiogenesis without the undesirable effects of administration of thalidomide.
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