Ganglioside GM3-containing nanoparticles as immunomodulators

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United States of America Patent

PATENT NO 11766462
APP PUB NO 20200330527A1
SERIAL NO

16957597

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention describes a pharmaceutical composition whose active ingredient includes conjugates of membrane vesicles of Neisseria meningitidis and the GM3 ganglioside in a conjugation ratio in excess of proteins, has particular characteristics of size, surface charge and a morphology associated with nano-particulate systems that give it advantageous properties as an immunomodulator, because it induces a convenient and significant reduction of myeloid-derived suppressor cells that has an impact on the response of lymphocytes and on the survival of patients with tumors. The invention further discloses the use of the pharmaceutical composition disclosed in the treatment of cancer, particularly those cancers where the myeloid-derived suppressor cells (MDSCs) are high; as well as a method of treatment with said composition in cancer patients and a method to select those who will receive said treatment.

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Patent Owner(s)

  • CENTRO DE INMUNOLOGÍA MOLECULAR

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Aguiar, García Lena Prov. Artemisa, CU 1 1
Alvarez, Arzola Rydell Havana, CU 2 1
Curbelo, Haredia Idelmis Havana, CU 2 1
Fernández, Gómez Audry Havana, CU 4 2
Fernández, Molina Luis Enrique Havana, CU 7 23
Gracia, Medina Elias Antonio Havana, CU 2 1
Hernández, de La Rosa Lourdes Havana, CU 3 1
Mesa, Pardillo Circe Havana, CU 8 7
Oliver, Ríos Liliana Havana, CU 1 1
Pérez, Ruíz Leslie Plaza de la Revolución, CU 1 1
Peña, Sánchez Vladimir Havana, CU 1 1
Rábade, Chediak Maura Lisett Havana, CU 3 2
Rodríguez, Rodríguez Camilo Plaza de la Revolución, CU 1 1
Rubio, Hernández María Caridad Havana, CU 1 1
Valdés, Guerrero Orlando Havana, CU 2 1
Valdés, Zayas Anet Havana, CU 2 1

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