Ganglioside GM3-containing nanoparticles as immunomodulators
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United States of America Patent
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Sep 26, 2023
Grant Date -
Oct 22, 2020
app pub date -
Dec 17, 2018
filing date -
Dec 27, 2017
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Abstract
The present invention describes a pharmaceutical composition whose active ingredient includes conjugates of membrane vesicles of Neisseria meningitidis and the GM3 ganglioside in a conjugation ratio in excess of proteins, has particular characteristics of size, surface charge and a morphology associated with nano-particulate systems that give it advantageous properties as an immunomodulator, because it induces a convenient and significant reduction of myeloid-derived suppressor cells that has an impact on the response of lymphocytes and on the survival of patients with tumors. The invention further discloses the use of the pharmaceutical composition disclosed in the treatment of cancer, particularly those cancers where the myeloid-derived suppressor cells (MDSCs) are high; as well as a method of treatment with said composition in cancer patients and a method to select those who will receive said treatment.
First Claim
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- 10 France
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- 2 Other
Patent Owner(s)
- CENTRO DE INMUNOLOGÍA MOLECULAR
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- [Patents Count]
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Aguiar, García Lena | Prov. Artemisa, CU | 1 | 1 |
Alvarez, Arzola Rydell | Havana, CU | 2 | 1 |
Curbelo, Haredia Idelmis | Havana, CU | 2 | 1 |
Fernández, Gómez Audry | Havana, CU | 4 | 2 |
Fernández, Molina Luis Enrique | Havana, CU | 7 | 23 |
Gracia, Medina Elias Antonio | Havana, CU | 2 | 1 |
Hernández, de La Rosa Lourdes | Havana, CU | 3 | 1 |
Mesa, Pardillo Circe | Havana, CU | 8 | 7 |
Oliver, Ríos Liliana | Havana, CU | 1 | 1 |
Pérez, Ruíz Leslie | Plaza de la Revolución, CU | 1 | 1 |
Peña, Sánchez Vladimir | Havana, CU | 1 | 1 |
Rábade, Chediak Maura Lisett | Havana, CU | 3 | 2 |
Rodríguez, Rodríguez Camilo | Plaza de la Revolución, CU | 1 | 1 |
Rubio, Hernández María Caridad | Havana, CU | 1 | 1 |
Valdés, Guerrero Orlando | Havana, CU | 2 | 1 |
Valdés, Zayas Anet | Havana, CU | 2 | 1 |
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