Promiscuous HER-2/Neu CD4 T cell epitopes
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United States of America Patent
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Jul 5, 2011
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app pub date -
Aug 9, 2007
filing date -
Aug 11, 2006
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Abstract
The present invention relates to the discovery of novel T cell epitopes of the human HER-2/Neu protein that is promiscuous for at least 25 different HLA-DR alleles. The invention also relates to compositions that contain one of the novel epitopes or a fusion peptide of such a epitope and a heterologous polypeptide. Further disclosed herein is the use of the epitopes or their fusion peptides, and compositions containing the epitopes or their fusion peptides.
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