Methods of and compositions for potentiating the action of agents active on cell wall sites of the susceptible bacteria
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United States of America Patent
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Nov 5, 2002
Grant Date -
Apr 25, 2002
app pub date -
Aug 26, 1998
filing date -
Jan 25, 1996
priority date (Note) -
Expired
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Abstract
The invention provides a method of potentiating the activity of antibacterial agents that act on bacterial cell walls, comprising the step of administering to a subject an antibacterial agent and an aminoglycoside to attain a peak concentration of at least 4 mg/l of aminoglycoside and thereafter maintaining the aminoglycoside at a concentration of up to 4 mg/l for at least 1 hour. Compositions comprising an antibacterial agent and an aminoglycoside for efficacious treatment of bacterial infection are also provided.
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