Methods for DNA-dependent targeting of a cell permeant antibody

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United States of America Patent

PATENT NO 11453725
SERIAL NO

16544625

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Abstract

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The invention provides methods for selective targeting of live cells, which have undergone or are undergoing radiation or chemotherapy, at a site of interest with a cell-penetrating polypeptide. In one embodiment of the invention, the method comprises contacting the live cells with a cell-penetrating polypeptide comprising cell-penetrating determinants so that the cell-penetrating polypeptide binds extracellular DNA near or around the live cells so as to form a complex or association therewith such that the complex or associated polypeptide-DNA so bound bind the live cells and penetrates the live cells thereby selectively targeting live cells at a site of interest with a cell-penetrating polypeptide.

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Patent Owner(s)

  • THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Nishimura, Robert N Sepulveda, US 17 67
Weisbart, Richard H Sepulveda, US 31 222

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