4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
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United States of America Patent
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Dec 16, 2003
Grant Date -
Feb 20, 2003
app pub date -
Dec 1, 2000
filing date -
Dec 2, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
This invention pertains to compounds having the structure: ##STR1## wherein NR.sub.1 R.sub.2 is a substituted or unsubstituted 4-8 membered ring; wherein R.sub.3 is a substituted or unsubstituted four to six membered ring; wherein R.sub.5 is H, alkyl, substituted alkyl, aryl, arylalkyl, amino, substituted aryl; wherein R.sub.6 is H, alkyl, substituted alkyl, or cycloalkyl; with the proviso that NR.sub.1 R.sub.2 is not 3-acetamido piperadino, 3-hydroxy pyrrolidino, 3-methyloxy carbonylmethyl pyrolidino, or 3-aminocarbonylmethyl pyrrolidino; with the proviso that NR.sub.1 R.sub.2 is 3-hydroxymethyl piperadino only when R.sub.3 is 4-pyridyl; which specifically inhibit the adenosine A.sub.2a receptor and the use of these compounds to treat a disease associated with A.sub.2a adenosine receptor in a subject, comprising administering to the subject a therapeutically effective amount of the compounds.
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