Scalable experimental workflow for parameter estimation
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United States of America Patent
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Jun 27, 2023
Grant Date -
Feb 4, 2021
app pub date -
Jul 31, 2019
filing date -
Jul 31, 2019
priority date (Note) -
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Abstract
The present disclosure relates to a scalable experimental workflow that uses a culture system to maintain a steady state in a biological system, and techniques for identifying values for parameters in a in silico model based on experimental data obtained from the biological system. Particularly, aspects of the present disclosure are directed to obtaining measurement data for one or more characteristics of a biological system developed in a culture system, where the measurement data is indicative of each of the one or more characteristics at a physiological steady state where growth of the biological system is occurring at a substantially constant growth rate, determining a value for a parameter of a model of the biological system based on an growth formula, the measurement data, and the substantially constant growth rate, and parametrizing the model with at least the value determined for the parameter.
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