Catalytically active recombinant memapsin and methods of use thereof
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United States of America Patent
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Nov 9, 2010
Grant Date -
May 15, 2008
app pub date -
Aug 3, 2007
filing date -
Jun 28, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
M against recombinant pro-memapsin 2. Crystallography of memapsin 2 bond to this inhibitor was used to determine the three dimensional structure of the protein, as well as the importance of the various residues in binding. This information can be used by those skilled in the art to design new inhibitors, using commercially available software programs and techniques familiar to those in organic chemistry and enzymology, to design new inhibitors to memapsin 2, useful in diagnostics and for the treatment and/or prevention of Alzheimer's disease.
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