Apparatus for parallel high-performance liquid chromatography with serial injection
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United States of America Patent
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Dec 10, 2002
Grant Date -
Feb 21, 2002
app pub date -
Sep 18, 2001
filing date -
Apr 2, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
High-performance liquid chromatography (HPLC) methods and systems are disclosed that combine sequential, serial injection of a plurality of samples into mobile-phases supplied in parallel to two or more chromatographic columns, such that staggered, parallel separation of the plurality of samples is effected. Because injection of samples is relatively fast as compared to separation, substantial efficiencies are gained with respect to overall sample throughput. The disclosed HPLC methods and systems are preferably applied in connection with combinatorial chemistry, combinatorial material science and more particularly, combinatorial synthesis and screening of polymeric materials.
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