Detection and recognition of analytes based on their crystallization patterns
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United States of America Patent
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May 6, 2008
Grant Date -
Dec 7, 2006
app pub date -
Apr 5, 2006
filing date -
Apr 5, 2005
priority date (Note) -
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Abstract
The invention contemplates a method for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as 'crystallization pattern') containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. It has been shown that changes in the crystallization patterns of a number of amino-acids can be used as a 'signature' of a protein added. It was also found that both the character of changer in the crystallization patter and the fact of such changes can be used as recognition elements in analysis of protein molecules.
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