Method for identifying JNK and MLK inhibitors for treatment of neurological conditions
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United States of America Patent
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Sep 4, 2007
Grant Date -
Aug 7, 2003
app pub date -
Feb 5, 2003
filing date -
May 14, 1998
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Abstract
The present invention describes methods for identifying compounds that inhibit JNK and MLK kinase activity as drugs for treating a mammal susceptible to or having a neurological condition. This invention also discloses methods for preventing neuronal cell death and treating neurological conditions that involve neuronal cell death, particularly neurodegenerative diseases characterized by glutamine or kainate mediated toxicity, such as Huntington's disease and Alzheimer's disease.
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