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Abstract

Disclosed is a method of treating a subject with a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to the subject a therapeutically effective amount of a compound represented by the following structural formula: ##STR1## and physiologically acceptable salts thereof. Z is a cycloalkyl or non-aromatic heterocyclic ring group fused to one or more carbocyclic aromatic rings and/or heteroaromatic rings, wherein each ring in Z is independently substituted or unsubstituted; Y is a covalent bond, --O-- or --CO--; n is an integer from one to about five; X is a covalent bond or --CO--; and M is >NR.sub.2, >CR.sub.1 R.sub.2 ; R.sub.1 is --H, --OH, an aliphatic group, --O--(aliphatic group), --SH or --S--(aliphatic group); R.sub.2 is an aliphatic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group, a benzylic group, a substituted benzylic group, a non-aromatic heterocyclic group or a substituted non-aromatic heterocyclic group.

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