Materials and methods for delivering nucleic acids to cochlear and vestibular cells

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United States of America Patent

PATENT NO 11730827
APP PUB NO 20190351072A1
SERIAL NO

16483668

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Abstract

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Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells, and methods of treating sensory transduction disorders associated with a genetic defect. Some embodiments are directed to a synthetic inner ear hair cell targeting adeno-associated virus (AAV) vector, a cell comprising the synthetic inner ear hair cell targeting AAV vector, and method of treating Usher Syndrome in a subject using the synthetic inner ear hair cell targeting AAV vector.

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Patent Owner(s)

  • CHILDREN'S MEDICAL CENTER CORPORATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Asai, Yukako Boston, US 3 0
Geleoc, Gwenaelle Boston, US 4 5
Holt, Jeffrey Boston, US 16 94

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