Interleukin-15 antagonist peptide
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United States of America Patent
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Jun 15, 2010
Grant Date -
May 28, 2009
app pub date -
Sep 16, 2005
filing date -
Sep 17, 2004
priority date (Note) -
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Abstract
Current invention is related to the molecular pharmacology branch particularly to a peptide belonging to the Interleukin-15 sequence (IL-15) which is able to inhibit IL-15 biological activity, analogues or mimetic of such peptides. In the current invention it is shown that the peptide inhibits both IL-15-induced T cells proliferation upon binding to the IL15 receptor a subunit (IL15Rα) and TNFα-mediated apoptosis.Besides, this invention is related to the use of this peptide in the treatment of several pathologies where aberrant IL-15 or IL-15Rα expression is associated to the disease progression.
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