Cell cycle arrest and apoptosis
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United States of America Patent
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Jul 5, 2011
Grant Date -
Dec 4, 2008
app pub date -
Oct 21, 2004
filing date -
Oct 21, 2004
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Abstract
lymphocytes results in G2 arrest, followed by apoptosis. ATR, as a cellular factor that mediates Vpr-induced cell cycle arrest, is required for activation of the Breast Cancer-Associated Protein-1 (BRCA1). In addition, the Growth Arrest and DNA Damage protein (GADD45) is upregulated by Vpr in an ATR-dependent manner. Posttranscriptional silencing of either ATR or GADD45 leads to nearly complete suppression of the pro-apoptotic and/or cell cycle arrest effect of Vpr.
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