Cationic substituted benzofurans as antimicrobial agents
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United States of America Patent
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Aug 26, 2008
Grant Date -
Sep 8, 2005
app pub date -
Dec 6, 2004
filing date -
Dec 5, 2003
priority date (Note) -
Expired
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Abstract
A method of treating a Mycobacterium tuberculosis infection in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of treating microbial infections, including infections from protozoan pathogens, such as Leishmania donovani, Trypanosoma brucei rhodesiense, a Trypanosoma cruzi, and Plasmodium falciparum, and fungal pathogens, such as Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans, in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of synthesizing novel cationic substituted benzofuran compounds and the novel compounds themselves.
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