Mandelic acid derivatives and their use as thrombin inhibitors
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United States of America Patent
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Oct 31, 2006
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app pub date -
Nov 30, 2001
filing date -
Dec 1, 2000
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Abstract
There is provided a compound of formula I ##STR00001## wherein R.sup.a, R.sup.1, R.sup.2, Y and R.sup.3 have meanings given in the description and pharmaceutically-acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
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