Vectors and methods for regenerative therapy

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United States of America Patent

PATENT NO 11331377
APP PUB NO 20180117125A1
SERIAL NO

15566987

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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An expression vector capable of disrupting the silencing of cell cycle genes in adult cells, such as adult cardiac myocytes and other quiescent cells in terminally differentiated tissues, comprising: (a) a nucleic acid sequence encoding lysine-specific demethylase 4D (KDM4D); (b) a promoter that induces or effects overexpression of KDM4D, wherein the promoter is operably linked to the nucleic acid sequence; and (c) a regulatory element that inducibly represses the overexpression of KDM4D. The vector can be administered to a subject in a method for inducing tissue-specific hyperplasia in a mammal, including cardiomyocyte proliferation. The method provides for regenerative therapy, including improving cardiac function after myocardial infarct and other forms of cardiac damage.

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Patent Owner(s)

  • BOARD OF REAGENTS OF THE UNIVERSITY OF WASHINGTON

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
El-Nachef, Danny Seattle, US 3 2
Maclellan, W Robb Seattle, US 3 2

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