Tetramaleimide linkers and use thereof

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United States of America Patent

PATENT NO 11666623
APP PUB NO 20210128668A1
SERIAL NO

16638624

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Abstract

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The present invention is directed to tetramaleimide linkers and use thereof, more specifically to the compounds represented by formula I and their use in the preparation of antibody-drug conjugates (ADCs). The ADCs obtained from the tetramaleimide linkers have high homogeneity and stability, and could be used effectively for the treatment of various diseases including tumors. The definition of the groups in formula I is the same as that in the description.

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Patent Owner(s)

  • NEWBIO THERAPEUTICS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
An, Deqiang Shanghai, CN 7 13
Han, Nianhe Shanghai, CN 37 480
Li, Huali Shanghai, CN 3 0
Wang, Baoxiang Shanghai, CN 3 0
Yang, Chun Shanghai, CN 75 687
Zeng, Di Shanghai, CN 25 80
Zhu, Peng Shanghai, CN 63 484

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