Ketoreductase polypeptides for the reduction of acetophenones

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United States of America Patent

PATENT NO 11479756
APP PUB NO 20210139861A1
SERIAL NO

17149463

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Abstract

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The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.

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Patent Owner(s)

  • CODEXIS INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ching, Charlene San Jose, US 26 307
Gruber, John M Mountain View, US 39 546
Huisman, Gjalt W Redwood City, US 144 2091
Jenne, Stephane J Foster City, US 21 615
Krebber, Anke Palo Alto, US 28 482
Liang, Jack South San Francisco, US 45 428
Mundorff, Emily Garden City, US 97 1174

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