Analogs of NT-3
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United States of America Patent
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Aug 7, 2001
Grant Date -
N/A
app pub date -
Feb 23, 1999
filing date -
Feb 23, 1999
priority date (Note) -
Expired
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Abstract
The in vivo circulating life and/or absorption of cationic therapeutic proteins, including but not limited to basic proteins such as NT-3, can be increased by generating analogs that have a lower isoelectric point and, preferably, also a lower protein charge relative to the protein of native sequence.
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