Preparation of virus-free antibodies
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United States of America Patent
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Oct 27, 1992
Issued Date -
N/A
app pub date -
Jan 29, 1990
filing date -
Apr 8, 1986
priority date (Note) -
Expired
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Abstract
Antibodies, including monoclonal antibodies (Mabs), can be made substantially free of infectious viruses by storing them in a liquid state at conditions of pH, temperature and time sufficient to inactive substantially all infectious viruses. Preferred inactivation methods involve use of a pH equal to or less than about 4.0 at a temperature of at least about 5.degree. C. for at least about 16 hours.
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