Therapeutic cationic peptides and unimolecular nanoparticles for efficient delivery thereof

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United States of America Patent

PATENT NO 11672766
APP PUB NO 20200276130A1
SERIAL NO

16845938

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Abstract

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Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be used in the treatment of breast cancer and other diseases or conditions in which PKM2 is overexpressed. Such PKM2 peptides may be delivered to cancer cells using pH sensitive unimolecular nanoparticles comprising anionic polymers.

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Patent Owner(s)

  • WISCONSIN ALUMNI RESEARCH FOUNDATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gong, Shaoqin Madison, US 101 356
Liu, Fabao Madison, US 2 0
Wang, Yuyuan Madison, US 9 0
Xu, Wei Middleton, US 846 7470

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