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Abstract

A compound of formula (I): ##STR00001## for use in treating cancer or other diseases ameliorated by the inhibition of PARP, wherein: A and B together represent an optionally substituted, fused aromatic ring; X can be NR.sup.X or CR.sup.XR.sup.Y; if X=NR.sup.X then n is 1 or 2 and if X=CR.sup.XR.sup.Y then n is 1; R.sup.X is selected from the group consisting of H, optionally substituted C.sub.1-20 alkyl, C.sub.5-20 aryl, C.sub.3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; R.sup.Y is selected from H, hydroxy, amino; or R.sup.X and R.sup.Y may together form a spiro-C.sub.3-7 cycloalkyl or heterocyclyl group; R.sup.C1 and R.sup.C2 are independently selected from the group consisting of hydrogen and C.sub.1-4 alkyl, or when X is CR.sup.XR.sup.Y, R.sup.C1, R.sup.C2, R.sup.X and R.sup.Y, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; R.sup.1 is selected from H and halo; and Het is selected from: ##STR00002## where Y.sup.1 is selected from CH and N, Y.sup.2 is selected from CH and N, Y.sup.3 is selected from CH, CF and N, where only one or two of Y.sup.1, Y.sup.2 and Y.sup.3 can be N; and ##STR00003## where Q is O or S.

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First Claim