Neuronal nicotinic acetylcholine receptor-targeting polypeptide and use thereof

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United States of America Patent

PATENT NO 11459356
APP PUB NO 20220242909A1
SERIAL NO

17329191

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A neuronal nicotinic acetylcholine receptor-targeting polypeptide and the use thereof are disclosed. The polypeptide has an amino acid sequence of SEQ ID NO:1, and includes four cysteine residues, Cys2, Cys3, Cys7, and Cys13, that can form two disulfide bonds. Molecular docking simulation illustrated its capacity to target a and a subunits of nAChR and the stable structure of resultant nAChR_BP-nAChR complex. In addition, effect of the polypeptide on calcium response of nAChR-overexpressing CN21 cells revealed that the polypeptide was capable of significantly inhibiting nAChRs. Accordingly, the nAChR-targeting polypeptide nAChR_BP is a promising nAChR-targeting drug.

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Inventor Name Address # of filed Patents Total Citations
Yu, Mingjia Foshan, CN 1 0

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