Programmed microorganisms to attenuate a disease

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United States of America Patent

PATENT NO 11898183
SERIAL NO

17344265

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Abstract

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The present disclosure discloses a recombinant microbe producing podophyllotoxin, or its derivatives, comprising genes encoding phenyl alanine ammonia-lyase (PAL), cinnamate-4-hydroxylate (C4H), 4-coumaroyl CoA-ligase (4CL), hydroxycinnamoyl-CoA quinate hydroxycinnamoyltransferase (HCT), p-coumaroyl quinate 3′-hydroxylase (C3H), caffeoyl CoA O-methyltransferase (CCoAOMT), bifunctional pinoresinol-lariciresinol reductase (DIRPLR), secoisolariciresinol dehydrogenase (SDH), cytochrome P450 oxidoreductase CYP719, O-methyltransferase (OMT), cytochrome P450 oxidoreductase CYP71, and 2-oxoglutarate/Fe(II)-dependent dioxygenase (2-ODD). Also disclosed herein is a method for producing podophyllotoxin or its derivatives. Moreover, a method of treating cancer is also disclosed.

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Patent Owner(s)

Patent OwnerAddress
MURALI PANCHAPAGESA MUTHUSWAMYTAMIL NADU

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kumar, Arumbuliyur Sathish Tamil Nadu, IN 1 0
Murali, Panchapagesa Muthuswamy Tamil Nadu, IN 4 39
Raghavan, Shriram Tamil Nadu, IN 3 3

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