Hepatocyte bioreactor system for long term culture of functional hepatocyte spheroids
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United States of America Patent
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Apr 1, 2008
Grant Date -
Apr 21, 2005
app pub date -
Feb 26, 2003
filing date -
Feb 26, 2002
priority date (Note) -
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Abstract
A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible.
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