Oral dosage form of ticagrelor and preparation method thereof

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United States of America Patent

PATENT NO 11723873
APP PUB NO 20220409545A1
SERIAL NO

17356120

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Abstract

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An oral dosage form of ticagrelor includes a core and a semi-permeable membrane coating the core. The core comprises a first drug layer and a push layer. The first drug layer contains ticagrelor that is sufficient to deliver an effective amount of the drug over an intended delivery time. The push layer comprises a swelling agent and an osmogen agent. The semi-permeable membrane has at least one passageway formed therethrough, positionally configured to face the first drug layer, but not to face the push layer, of the core, and functionally configured to allow the ticagrelor to realize an extended release out of the core upon contacting an aqueous environment. The dosage form optionally further includes a second ticagrelor-containing drug layer coating the semi-permeable membrane, thereby providing a starting effective dose upon administration. The dosage form can realize once-a-day administration of ticagrelor of patients in need thereof.

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Patent Owner(s)

  • ELITE PHARMACEUTICAL SOLUTION INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Tian, Henry Princeton, US 2 0
Tian, Wu Princeton, US 11 7
Wang, Yan Princeton, US 1060 6524

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