Nucleic acid detection combining amplification with fragmentation

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United States of America Patent

PATENT NO 11155877
APP PUB NO 20190100808A1
SERIAL NO

16165400

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Abstract

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Provided herein are methods and compositions for detection of a nucleic acid target in a sample. The methods and compositions use primer directed amplification in conjunction with nucleic acid fragmentation. The methods have high sensitivity even in the presence of a large amount of non-target nucleic acid. Also provided are oligonucleotides and kits useful in the method. Exemplary nucleic acid targets are those with mutant gene sequence such as mutant sequence of the EGFR, APC, TMPRSS2, ERG and ETV1 genes.

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Patent Owner(s)

  • QUEST DIAGNOSTICS INVESTMENTS LLC

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bender, Richard A Dana Point, US 7 30
Qu, Kevin Z Lake Forest, US 9 33
Sanders, Heather R RSM, US 25 74
Strom, Charles M San Clemente, US 21 107

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