Methods for expansion of hematopoietic stem and progenitor cells

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United States of America Patent

PATENT NO 8642569
APP PUB NO 20110305675A1
SERIAL NO

13145706

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Abstract

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Described herein are methods and compositions for expanding hematopoietic stem and progenitor cells (HSPC) ex vivo and in vivo, and methods and compositions for transplanting HSPCs and treatment of anemia in a human subject. HSPCs are expanded in the presence of an inhibitor of serine threonine kinase 38 (STK38), wherein said inhibitor is preferably an RNAi agent.

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Patent Owner(s)

  • THE GENERAL HOSPITAL CORPORATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Larsson, Jonas Lund, SE 23 55
Scadden, David Weston, US 10 11

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