Non-immunosuppressive immunogenic or vaccine composition comprising a mutated E7 protein of the HPV-16 virus
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United States of America Patent
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Jan 1, 2008
Grant Date -
Oct 19, 2006
app pub date -
Apr 4, 2003
filing date -
Apr 24, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention relates to an immunogenic or vaccine composition inducing an immune response towards the HPV-16 Papillomavirus native E7 protein, without simultaneously inducing an immunosuppression, said composition comprising, as the active ingredient, a non immunosuppressive mutated E7 protein, comprising the amino acid sequence consisting, from the N-terminal end to the C-terminal end, in: i. the 1-19 amino acid sequence of sequence SEQ ID No. 3; ii. an amino acid sequence possessing (a) the substitution of at least one amino acid, compared to the 20-29 corresponding amino acid sequence of sequence SEQ ID No. 3 or (b) the deletion of at least four consecutive amino acids, compared to the 20-29 corresponding amino acid sequence of sequence SEQ ID No. 3; and iii. the 30-98 amino acid sequence of sequence SEQ ID No 3.
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