Adenovirus vectors for gene therapy
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United States of America Patent
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Oct 31, 2000
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app pub date -
May 31, 1994
filing date -
Jun 24, 1993
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Abstract
The invention comprises a series of adenovirus-based vectors having deletions in the E1 and/or E3 regions, and also insertions of pBR322 sequences, which can be used to deliver nucleic acid inserts into host cells, tissues or organisms that then can express the insert. The invention includes the use of the vectors in introducing genes into cells, in making vaccines and in gene therapy.
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