Prognostic methods for prediction of progression of normal and hyperplastic mammary cells to carcinoma
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United States of America Patent
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Feb 3, 2004
Grant Date -
May 9, 2002
app pub date -
Oct 18, 1996
filing date -
Oct 18, 1995
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Abstract
The present invention encompasses methods for determining the likelihood that benign hyperplastic breast tissue or normal breast tissue adjacent to carcinoma tissue will become malignant. The methods comprise substantially isolating the tissue; and determining loss of heterozygosity (LOH) at chromosome 3p24 in the tissue. LOH at chromosome 3p24 is a prognostic indicator that the tissue may become malignant.
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