Metadherin polypeptides, encoding nucleic acids and methods of use
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United States of America Patent
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Jul 14, 2009
Grant Date -
Sep 22, 2005
app pub date -
Nov 10, 2004
filing date -
Nov 13, 2003
priority date (Note) -
Expired
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Abstract
Metadherin, a protein that controls metastasis, and variants of metadherin are described. DNA sequences encoding the same and methods of production are described. Therapies involving the application of metadherin, binding agents that bind to metadherin, such as antibodies, and expression modulating agents, such as siRNA, are described. The use of metadherin or metadherin variants for delivering desired substances to particular lung tissue is described. A method of diagnosing metastatic cells based on the presence of metadherin is described.
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