Liquid adenovirus formulations
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United States of America Patent
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Feb 15, 2011
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app pub date -
Jun 26, 2007
filing date -
Nov 16, 1998
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Abstract
The present invention addresses the need to improve the long-term storage stability (i.e. infectivity) of vector formulations. In particular, it has been demonstrated that for adenovirus, the use of bulking agents, cryoprotectants and lyoprotectants imparts desired properties that allow both lyophilized and liquid adenovirus formulations to be stored at 4° C. for up to 6 months and retain an infectivity between 60-100% of the starting infectivity.
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