GLP-1 receptor modulators

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United States of America Patent

PATENT NO 9260427
SERIAL NO

14302260

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Abstract

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Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “” represents either or both the R and S form of the compound):

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Patent Owner(s)

  • CELGENE INTERNATIONAL II SÀRL

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boehm, Marcus F San Diego, US 79 968
Brahmachary, Enugurthi San Diego, US 24 228
Fowler, Thomas Melton Mowbray, GB 18 184
Huang, Liming San Diego, US 66 606
Knaggs, Michael Burton-on-Trent, GB 14 224
Martinborough, Esther San Diego, US 85 882
Meghani, Premji Loughborough, GB 55 560
Moorjani, Manisha San Diego, US 34 292
Novak, Andrew Long Eaton, GB 31 162
Tamiya, Junko Carlsbad, US 35 288
Yeager, Adam R La Mesa, US 10 66

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