Intercalators having affinity for DNA and methods of use
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United States of America Patent
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Feb 4, 1997
Issued Date -
N/A
app pub date -
Jun 5, 1995
filing date -
Jun 30, 1993
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Abstract
Intercalator compounds are provided which are comprised of intercalator moieties, or substituted intercalator moieties, having one or more functionalized chains, or moieties, and which compounds provide a high affinity for binding to the DNA molecule and show reduced self-quenching, while providing superior transport kinetics. The compounds have been found to provide enhanced fluorescence when bound to a DNA molecule within a fluorescent flow cytometry environment which is about eight to ten times brighter in fluorescence than 'bis' structure conventional intercalating agents and other known intercalating agents utilized in flow cytometry environment.
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