17-hydroxyprogesterone ester-containing oral compositions and related methods

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United States of America Patent

PATENT NO 11471470
SERIAL NO

16926506

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Abstract

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The present invention provides for bioavailable oral dosage forms containing esters of 17-hydroxyprogesterone as well as related methods. The oral dosage forms can be formulated for pregnancy support and can include a therapeutically effective amount of an ester of 17-hydroxyprogesterone and a pharmaceutically acceptable carrier. In another embodiment, a pharmaceutically acceptable oral dosage form for pregnancy support is provided. The pharmaceutically acceptable oral dosage can include a therapeutically effective amount of an ester of 17-hydroxyprogesterone and a pharmaceutically acceptable carrier. The oral dosage form can, when measured using a USP Type-II dissolution apparatus in 900 mL of deionized water with 0.5 (w/v) of sodium lauryl sulfate at 50 RPM at 37° C., release at least 20 wt % of the dose of the ester of 17-hydroxyprogesterone after 60 minutes, or in the alternative release at least 20 wt % more after 60 minutes than an equivalently dosed oral dosage form without the carrier.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chickmath, Basawaraj Minneapolis, US 47 795
Chidambaram, Nachiappan Sandy, US 130 852
Giliyar, Chandrashekar Plymouth, US 98 1900
Nachaegari, Satish Kumar Holladay, US 46 568
Patel, Mahesh V Salt Lake City, US 173 9231
Venkateshwaran, Srinivansan Salt Lake City, US 44 497

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