Methods to further enhance signal amplification for the in situ detection of nucleic acids

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United States of America Patent

PATENT NO 11788124
APP PUB NO 20210032690A1
SERIAL NO

17046228

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to detection of nucleic acids and provides a composition comprising a Signal Generating Complex, wherein the composition comprises: (A) a pair of target probes (TPs), wherein a first TP of the pair of TPs comprises a nucleic acid sequence comprising two segments; (B) a pair of base PPAs comprising the first and second base PPAs, wherein the first base PPA comprises a nucleic acid sequence comprising three segments; (C) a set of extension PPAs comprising the first and second extension PPAs, wherein the first extension PPA comprises a nucleic acid sequence comprising two segments; (D) a plurality of pre-amplifiers (PAs), wherein the PAs comprise a nucleic acid sequence comprising three segments; (E) a plurality of amplifiers (AMPs), wherein the AMPs comprise a nucleic acid sequence comprising two segments; and (F) a plurality of label probes (LPs), wherein the LPs comprise a nucleic acid sequence comprising two segments.

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Patent Owner(s)

  • ADVANCED CELL DIAGNOSTICS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Steve Newark, US 71 1981
Doolittle, Emerald Newark, US 2 0
Jarnagin, Helen Newark, US 1 0
Luo, Yuling Newark, US 56 1496
Ma, Xiao-Jun Newark, US 72 471
Pimentel, Xiao Yan Newark, US 1 0
Su, Nan Newark, US 16 162
Wang, Xiaoming Newark, US 156 791
Wu, Xingyong Newark, US 11 249
Zhang, Bingqing Newark, US 9 0

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