Method of monitoring redox of blood plasma using ESR and method of estimating progress of dialysis
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United States of America Patent
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Mar 11, 2003
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N/A
app pub date -
Feb 3, 1999
filing date -
Feb 3, 1998
priority date (Note) -
Expired
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Abstract
A method of judging the redox (oxidation-reduction) in human blood plasma precisely in a short time using electron spin resonance (ESR) spectroscopy is provided. Also, a method of evaluating the functions of human kidneys, judging whether a dialysis is necessary, determining the dialysis time and judging the usefulness of dialysis materials is offered. First, a spin-trapping agent such as PBN is added to a human blood plasma, resulting in hydroxyl radicals in the plasma. The radicals are trapped and converted into a stable spin adduct (PBN-OH). The amount of the spin adduct is measured by an ESR spectrometer.
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