Artificial tendon or ligament tissue produced using three-dimensional mechanosignaling cell culture system

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United States of America Patent

PATENT NO 11773376
SERIAL NO

16630188

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to providing artificial tendon or ligament tissue having sufficient strength. More specifically, artificial tendon or ligament tissue having sufficient strength is provided by embedding collagen-secreting cells in a gel having strength capable of resisting a tensile load and by culturing the cells while applying a tensile load to the gel to produce artificial tendon or ligament tissue. Cells that steadily express the Mkx gene can be used as the collagen-secreting cells. A fibrin gel containing aprotinin can be used as the gel.

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Patent Owner(s)

  • NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Asahara, Hiroshi Tokyo, JP 6 0
Chiba, Tomoki Tokyo, JP 7 2
Kataoka, Kensuke Tokyo, JP 2 0

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