Artificial oocyte activation

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United States of America Patent

PATENT NO 10190093
APP PUB NO 20180094240A1
SERIAL NO

15726672

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Abstract

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The present invention provides novel methods for improving the efficiency of artificial activation of unfertilized mammalian oocytes by reducing the intracellular concentration of Zn2+ in the oocyte. The methods of the invention may additionally comprise a preceding step of increasing the intracellular concentration of Ca2+ in the oocyte prior to reduction of the intracellular Zn2+ concentration. The invention further provides unfertilized oocytes activated by the disclosed methods and viable mammalian animals produced from unfertilized oocytes activated by the disclosed methods.

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Patent Owner(s)

  • THE CURATORS OF THE UNIVERSITY OF MISSOURI

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lee, Kiho Columbia, US 28 366
Prather, Randall S Columbia, US 30 246

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