5-fluorouracil derivatives, preparation methods and uses thereof

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United States of America

PATENT NO 11279678
APP PUB NO 20210230122A1
SERIAL NO

16762238

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Abstract

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Disclosed is a 5-fluorouracil derivative having the molecular structure shown in general formula VI, in which Ra and Rb groups are an alkoxy group or a fluorine-substituted alkoxy group having 1, 2, 3, or 4 carbon atoms, and are mono-, bis-, tri-, tetra- or penta-substituted on a phenyl group; a linking group L1 is an alkyl or alkenyl group having 1, 2, 3, or 4 carbon atoms, a linking group L2 is oxygen, or an alkyl or alkoxy group having 1, 2, 3, or 4 carbon atoms, or an amino acid, or an alkyl group having 1, 2, 3, or 4 carbon atoms containing an amino moiety, or a furyl group, and an X group is O or —NH—. Further disclosed is a method for preparing such a derivative and a use of the same in the treatment of cancer, tumor diseases, and diseases caused by abnormal neovascularization in a human or non-human mammal, and a medicament or a composition containing the 5-fluorouracil derivative.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Huang, Jinwen Shanghai, CN 3 2
Ma, Zhonglin Shanghai, CN 9 43
Pang, Wan Shanghai, CN 1 0
Wu, Fanhong Shanghai, CN 3 0
Wu, Jianyue Shanghai, CN 1 0
Yu, Xiaodong Shanghai, CN 129 379
Zhang, Zhikai Shanghai, CN 3 0
Zhao, Lei Shanghai, CN 333 2357
Zhou, Jiujiu Shanghai, CN 1 0

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