Process for the preparation of (6S)- and (6R)-tetrahydrofolic acid
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United States of America Patent
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Jun 28, 1994
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app pub date -
Apr 8, 1993
filing date -
Jan 16, 1991
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Abstract
For the preparation of (6S)- and (6R)-tetrahydrofolic acid and their addition salts with a sulfonic acid or with sulfuric acid, (6R,S)-tetrahydrofolic acid is reacted with a sulfonic acid or with sulfuric acid, the resulting acid addition salt is fractionally crystallized and, if desired, the (6S)- or (6R)-tetrahydrofolic acid is liberated from the resulting diastereomeric acid addition salts by treatment with a base and isolated.
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