PCSK9 targeting oligonucleotides for treating hypercholesterolemia and related conditions

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United States of America Patent

PATENT NO 11566248
APP PUB NO 20210238606A1
SERIAL NO

17048846

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Abstract

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This disclosure relates to oligonucleotides, compositions and methods useful for reducing PCSK9 expression, particularly in hepatocytes. Disclosed oligonucleotides for the reduction of PCSK9 expression may be double-stranded or single-stranded, and may be modified for improved characteristics such as stronger resistance to nucleases and lower immunogenicity. Disclosed oligonucleotides for the reduction of PCSK9 expression may also include targeting ligands to target a particular cell or organ, such as the hepatocytes of the liver, and may be used to treat hypercholesterolemia, atherosclerosis, and/or one or more symptoms or complications thereof.

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Patent Owner(s)

Patent OwnerAddress
DICERNA PHARMACEUTICALS INC75 HAYDEN AVENUE LEXINGTON MA 02421

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dudek, Henryk T Wellesley, US 65 169
Park, Jihye Lexington, US 15 37

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