Plant lectins as carriers of associated drug substances into animal and human cells

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United States of America Patent

PATENT NO 11377649
APP PUB NO 20170267987A1
SERIAL NO

15606830

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Abstract

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The current invention involves the use of protein lectins produced by plants including the non-toxic carbohydrate binding subunits (B subunits) of plant “AB toxins” (PTB lectins) as delivery vehicles for mobilizing associated drug substances for delivery to animal and human cells. The resulting protein fusions or conjugates retain lectin carbohydrate specificity for binding to cells and cellular trafficking activity so as to deliver an associated drug compound to the site of disease manifestation. One embodiment of this invention concerns the ability of ricin toxin B subunit, as a model PTB lectin, to deliver enzyme replacement therapeutic drugs to cells of several organs of the body including the brain and central nervous system, eyes, ears, lungs, bone, heart, kidney, liver, and spleen for treating lysosomal diseases.

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  • BIOSTRATEGIES LC

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cramer, Carole L Jonesboro, US 6 113
Radin, David N Jonesboro, US 10 118

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