Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
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United States of America Patent
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Oct 5, 2010
Grant Date -
Apr 15, 2010
app pub date -
Jun 29, 2009
filing date -
Mar 14, 2001
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Abstract
A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications.
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- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
- UNIVERSITY OF HOUSTON
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- [Patents Count]
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Gao, Xiaolian | Houston, US | 68 | 2899 |
Leproust, Eric | Campbell, US | 11 | 306 |
Pellois, Jean Philippe | New York, US | 8 | 214 |
Xiang, Qin | Houston, US | 6 | 199 |
Yu, Peilin | Houston, US | 9 | 227 |
Zhang, Hua | Houston, US | 487 | 2878 |
Zhou, Xiaochuan | Houston, US | 40 | 1359 |
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Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
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