Transcriptional co-repressor that interacts with nuclear hormone receptors and uses therefor
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United States of America Patent
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Sep 18, 2007
Grant Date -
Jul 24, 2003
app pub date -
Jan 23, 2003
filing date -
Sep 1, 1995
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Abstract
In accordance with the present invention, there are provide novel receptor interacting factors, referred to herein as 'SMRT', i.e., a silencing mediator (co-repressor) for retinoic acid receptor (RAR) and thyroid hormone receptor (TR). SMRT is a novel protein whose association with RAR and TR both in solution and on DNA response elements is destabilized by ligand. The interaction of SMRT with mutant receptors correlates with the transcriptional silencing activities of receptors. In vivo, SMRT functions as a potent co-repressor. A GAL4 DNA binding domain (DBD) fusion of SMRT behaves as a frank repressor of a GAL4-dependent reporter. Together, these data identify a novel class of cofactor which is believed to represent an important mediator of hormone action.
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